浩瀚色谱（山东应用技术开发有限公司，）建立顶空气相色谱法测定聚乙二醇酯中的残留杂质环氧乙烷和二氧六环的含量。为1聚乙二醇酯的质量控制提供参考和依据。甲基聚硅氧烷为固定液,采用程序升温模式:起始温度为35℃,维持5 min,以每分钟5℃的速率升温至180℃,然后以每分钟30℃的速率升温至250℃,维持5 min。进样口温度为150℃,检测器温度为250℃,顶空平衡温度70℃,平衡时间45 min,分流比为10∶1。按标准加入法计算供试品中环氧乙烷和二氧六环的含量。结果:在该色谱条件下,环氧乙烷和二氧六环分别在0.5~4μg·mL^(-1)和5~40μg·mL^(-1)范围内线性关系良好(r≥0.99);平均回收率均为75%(RSD=5%,n=9)。结论:该方法适用于聚乙二醇酯中环氧乙烷和二氧六环含量测定,为聚乙二醇酯的质量控制提供了参考与指导。

　　GB 1886.302-2021 食品安全国家标准 食品添加剂 聚乙二醇

　　本标准适用于环氧乙烷和水缩聚而制得的食品添加剂聚乙二醇。

　　环氧乙烷和二氧六环的测定

　　名称:毛细管柱

　　型号:HH-1

　　规格:30m*0.32mm*0.5um

　　*高温度:300°C

　　编号:20240322002

　　应用:GB 1886.302-2021 食品安全国家标准 食品添加剂 聚乙二醇

　　Haohan Chromatography (Shandong Applied Technology Development Co., Ltd.) established a headspace gas chromatography method to determine the residual impurities of ethylene oxide and dioxane in polyethylene glycol esters. Provide reference and basis for the quality control of polyethylene glycol ester. Methyl polysiloxane is used as the fixed solution, and a programmed heating mode is adopted: the initial temperature is 35 ℃, maintained for 5 minutes, heated at a rate of 5 ℃ per minute to 180 ℃, and then heated at a rate of 30 ℃ per minute to 250 ℃, maintained for 5 minutes. The inlet temperature is 150 ℃, the detector temperature is 250 ℃, the headspace equilibrium temperature is 70 ℃, the equilibrium time is 45 minutes, and the split ratio is 10:1. Calculate the content of ethylene oxide and dioxane in the test sample using the standard addition method. Result: Under the chromatographic conditions, ethylene oxide and dioxane were found to be between 0.5 and 4, respectively μ G · mL ^ (-1) and 5-40 μ The linear relationship within the range of g · mL ^ (-1) is good (r ≥ 0.99); The average recovery rate is 75% (RSD=5%, n=9). Conclusion: This method is suitable for the determination of ethylene oxide and dioxane content in polyethylene glycol esters, providing reference and guidance for the quality control of polyethylene glycol esters.

　　GB 1886.302-2021 National Food Safety Standard Food Additive Polyethylene Glycol

　　This standard applies to the food additive polyethylene glycol produced by the condensation of ethylene oxide and water.

　　Determination of ethylene oxide and dioxane

　　Name: Capillary Column

　　Model: HH-1

　　Specification: 30m * 0.32mm * 0.5um

　　*High temperature: 300 ° C

　　Number: 20240322002

　　Application: GB 1886.302-2021 National Food Safety Standard Food Additive Polyethylene Glycol